Search results for "medicine absorption"

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Mucoadhesive Polymer Hyaluronan as Biodegradable Cationic/Zwitterionic-Drug Delivery Vehicle

2014

Mucoadhesive polymers in pharmaceutical formulations release drugs in mucosal areas. They interact and fix to mucus via molecular interpenetration, etc ., which increase drug bioavailability. Polymers physicochemical properties affect formulation mucoadhesion, rheological behaviour and drug absorption. Hyaluronan (HA) is selected as a mucoadhesive and biodegradable polymer. Geometric, topological and fractal analyses are carried out with program TOPO. Reference calculations are performed with algorithm GEPOL. Procedure TOPO underestimates molecular volume by 0.7%. Error results 5% in surface area and derived topological indices. Solvent-accessible surface is undercalculated by 3%: from hexa…

chemistry.chemical_classificationAbsorption (pharmacology)Chemistrylcsh:RM1-950Cationic polymerizationMedicine (miscellaneous)NanotechnologyPolymerBiodegradable polymerBioavailabilitymedicine absorption; medicine delivery; dipole moment; fractal dimension; metal hyaluronate; mucosalcsh:Therapeutics. PharmacologyChemistry (miscellaneous)Drug deliveryMucoadhesionPharmacology (medical)General Pharmacology Toxicology and PharmaceuticsHydrateNuclear chemistryADMET and DMPK

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